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Farmers have been using the weed killer glyphosate – a key ingredient of the product Roundup – at soaring levels even as glyphosate has become increasingly less effective and as health concerns and lawsuits mount. A review of the agency’s data by the Midwest Center for Investigative Reporting shows that farmers across the Midwest used an estimated 188.7 million pounds of glyphosate in 2016, nearly 40 times more than in 1992 when they used a total of 4.6 million pounds.