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Kessler's book depicts the investigation undertaken by the Food and Drug Administration (FDA) into the tobacco industry. The author, former FDA commissioner in the early 90s, uncovers "historical evidence that the tobacco companies orchestrated the greatest conspiracy ever undertaken to put the nation's health at risk." The book follows step by step the disclosure of scientific information and documents that proved the tobacco companies awareness that nicotine is an addictive drug. Kessler looks at the money and politics strings that tobacco industry has been controlling over the past decades.